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KMID : 1011320120050010010
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Journal of Pharmacoepidemiology and Risk Management
2012 Volume.5 No. 1 p.10 ~ p.14
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Incidence of Vancomycin-related Adverse Drug Reaction and the Way to Enhance Reports of Adverse Events
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Kim Do-Hyung
Kim Kyung-Mook
Kim Youn-Seup
Park Jae-Seuk
Jee Young-Koo
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Abstract
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Objective: To evaluate the incidence of vancomycin-related adverse drug reactions (ADRs) and to enhance the report rate of ADRs.
Methods: Surveillance for vancomycin-related ADRs was performed in a regional pharmacovigilance center of Dankook university hospital from July 1 to December 31 in 2010. Vancomycin-related ADRs were evaluated for skin reaction, gastrointestinal symptoms, drug fever, anaphylaxis, and abnormal laboratory tests including granulocytopenia, abnormal liver and renal function. The incidence of ADRs was compared before and after active surveillance, and was also compared based on 3 different vancomycin-producing pharmaceuticals.
Results: Among a total of 898 patients receiving vancomycin, 36 (4.0%) were defined as having vancomycin-induced ADRs. The most common ADRs were skin symptoms (26, 2.9%), and gastrointestinal symptoms occurred in 5 cases (0.6%), abnormal liver function in 2 cases (0.2%), fever in 1 case (0.1%), anaphylaxis in 1 case (0.1%), and granulocytopenia in 1 case (0.1%) in decreasing order. Despite lack of statistical significance, the report rate of vancomycin-related ADRs was higher during active surveillance period [24 (5%) vs. 12 (2.9%), p=0.096]. The incidence of vancomycin-related ADRs was not statistically different among 3 different pharmaceuticals [22 (3.7%) vs. 13 (4.6%) vs. 1 (4.2%), respectively, p=0.812].
Conclusion: The report rate of vancomycin-related ADRs was increased from 2.9% to 5.0% after active surveillance. Educating nurses about the knowledge of ADRs and encouraging their report can be an effective strategy to enhance the report rate of ADRs in a hospital.
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KEYWORD
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Vancomycin, Adverse events
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